Antimicrobial and Antibiofilm Activity of Methanol and Ethyl Acetate Extract of Ferula sp. Growing in Erzurum

Abstract

This study investigated the antimicrobial and antibiofilm activities of Ferula species obtained from Erzurum province. Antimicrobial activity against Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Enterococcus faecalis, Candida albicans, and C. tropicalis were determined by agar well diffusion test. No antimicrobial activity was detected against P. aeruginosa, E. faecalis, and C. tropicalis. Ethyl acetate extract showed antimicrobial activity against S. aureus, and methanol extract showed antimicrobial activity against E. coli and C. albicans with a zone diameter of 21, 18, 15 mm, respectively. Extract applications of >8%, 16%, and 32% to S. aureus, E. coli, and C. albicans, respectively, were the extract's minimum inhibitory concentrations (MICs). Furthermore, it was determined for the first time that Ferula sp. extracts obtained from Erzurum were effective against biofilm formations of S. aureus and C. albicans. In the light of these results, we think that extracts of Ferula species contain potential candidate molecules against biofilm-associated infections, and further characterization studies are needed.